From St. Louis County take I-270 South across the J.B. bridge until 270/255 intersects Route 3. Continue on Route 3 South 9.4 miles. Turn right onto HH Road (across from Bee Hive Bowl). Go 0.2 miles on HH and The Waterloo Inn Bed & Breakfast is on the right.

From Downtown St. Louis or northern Illinois counties take I-255 South until you reach the Route 3 (Columbia) exit. Continue on Route 3 South 9.4 miles.Turn right onto HH Road (across from Bee Hive Bowl). Go 0.2 miles on HH and The Waterloo Inn Bed & Breakfast is on the right.